Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7.

@article{Lissitzky2000EndoproteolyticPO,
  title={Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7.},
  author={J. C. Lissitzky and Jose Gato Luis and Jon Scott Munzer and Suzanne Benjannet and Fabrice Parat and M Chr{\'e}tien and Jacques Marvaldi and Nabil G Seidah},
  journal={The Biochemical journal},
  year={2000},
  volume={346 Pt 1},
  pages={133-8}
}
Several integrin alpha subunits undergo post-translational endoproteolytic processing at pairs of basic amino acids that is mediated by the proprotein convertase furin. Here we ask whether other convertase family members can participate in these processing events. We therefore examined the endoproteolysis rate of the integrin subunits pro-alpha5, alpha6 and alphav by recombinant furin, proprotein convertase (PC)5A, paired basic amino acid converting enzyme (PACE)4, PC1, PC2 and PC7 in vitro and… CONTINUE READING

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