Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters.

@article{Qing2007EndoproteolyticPO,
  title={Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters.},
  author={Guoliang Qing and Zhaoxia Qu and Gutian Xiao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 13},
  pages={5324-9}
}
The C-terminal, partially truncated forms of the NF-kappaB2/p52 precursor p100, p100DeltaCs, manifest constitutive processing and oncogenic ability, although the responsible mechanisms remain unknown. Here, we report that p100DeltaCs are specifically processed in association with binding to promoter DNA-containing kappaB sites. In the nucleus, p100DeltaCs bind to the kappaB promoter DNA and subsequently recruit the proteasome to form a stable proteasome/p100DeltaC/DNA complex, which mediates… CONTINUE READING

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