Endoplasmic reticulum stress response as a possible mechanism of cyclooxygenase-2-independent anticancer effect of celecoxib.

@article{Cha2014EndoplasmicRS,
  title={Endoplasmic reticulum stress response as a possible mechanism of cyclooxygenase-2-independent anticancer effect of celecoxib.},
  author={Wonjae Cha and Seok-Woo Park and T K Kwon and Jeong Hun Hah and Myung-Whun Sung},
  journal={Anticancer research},
  year={2014},
  volume={34 4},
  pages={1731-5}
}
BACKGROUND We investigated whether the endoplasmic reticulum (ER) stress response could be a cyclooxygenase-2 (COX2)-independent mechanism of growth inhibition by celecoxib in a head and neck squamous cell carcinoma (HNSCC) cell line. MATERIALS AND METHODS We performed western blotting and reverse transcription polymerase chain reaction to analyze the expression of ER stress response-associated proteins C/EBP homologous protein (CHOP), glucose-regulated protein (GRP)-78 and X-box binding… CONTINUE READING