Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters

@inproceedings{Usuki2017EndoplasmicRS,
  title={Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters},
  author={Fusako Usuki and Masatake Fujimura and Akio Yamashita},
  booktitle={Scientific Reports},
  year={2017}
}
Endoplasmic reticulum (ER) stress preconditioning protects cells against methylmercury (MeHg) cytotoxicity by inducing integrated stress responses such as eIF2α phosphorylation, ATF4 accumulation, and nonsense-mediated mRNA decay (NMD) suppression. Here we demonstrated that ER stress preconditioning results in the upregulation of membrane transporters, leading to a decrease in intracellular mercury content. Our analyses showed that ER stress preconditioning upregulated the expression of… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 43 REFERENCES

targeting the mTORC1 pathway to inhibit neoplasia

Q. Wang, Holst, J. L-type amino acid transport, cancer
  • Am. J. Cancer Res. 5, 1281–1294
  • 2015

High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4)

L Cheung
  • Biochem. Pharmacol
  • 2014

Role of amino acid transporters in amino acid sensing.

  • The American journal of clinical nutrition
  • 2014