Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renal proximal tubular epithelial cells.

@article{Zhu2012EndoplasmicRS,
  title={Endoplasmic reticulum stress mediates aristolochic acid I-induced apoptosis in human renal proximal tubular epithelial cells.},
  author={Shaohua Zhu and Yanli Wang and Jing Jin and Cuiwen Guan and Mei Li and Chen Jia Xi and Zizhang Ouyang and Meiwan Chen and Yuwen Qiu and Min Huang and Zhiying Huang},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2012},
  volume={26 5},
  pages={663-71}
}
Aristolochic acid (AA), derived from the Aristolochia species, has been associated with aristolochic acid nephropathy (AAN), which has emerged as a worldwide disease. Aristolochic acid I (AAI) is the main ingredient of AA, and the underlying mechanisms for AAI-induced nephrotoxicity are still unclear. In this study, we investigated whether endoplasmic reticulum (ER) stress was involved in AAI-induced nephrotoxicity. The results showed that treatment of HK-2 cells (a human proximal tubular… CONTINUE READING

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