Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain.

@article{Lin2007EndoplasmicRS,
  title={Endoplasmic reticulum stress is involved in arsenite-induced oxidative injury in rat brain.},
  author={Anya Maan-yuh Lin and Pei-dawn Lee Chao and Shang F Fang and C. W. Chi and Chae Ha Yang},
  journal={Toxicology and applied pharmacology},
  year={2007},
  volume={224 2},
  pages={138-46}
}
The mechanism underlying sodium arsenite (arsenite)-induced neurotoxicity was investigated in rat brain. Arsenite was locally infused in the substantia nigra (SN) of anesthetized rat. Seven days after infusion, lipid peroxidation in the infused SN was elevated and dopamine level in the ipsilateral striatum was reduced in a concentration-dependent manner (0.3-5 nmol). Furthermore, local infusion of arsenite (5 nmol) decreased GSH content and increased expression of heat shock protein 70 and heme… CONTINUE READING

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