Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice.

@article{Zhang2012EndoplasmicRS,
  title={Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice.},
  author={Cheng Zhang and Xi Chen and R M Zhu and Ying Zhang and Tao Yu and Hua Wang and Hui Zhao and Mei Ping Zhao and Yan-Li Ji and Yuan-hua Chen and Xiu Hong Meng and Wei Wei and De-Xiang Xu},
  journal={Toxicology letters},
  year={2012},
  volume={212 3},
  pages={229-40}
}
A link between fructose drinking and nonalcoholic fatty liver disease (NAFLD) has been demonstrated in human and rodent animals. The aim of the present study was to investigate whether endoplasmic reticulum (ER) stress is mediated in the development of fructose-induced NAFLD. Female CD-1 mice were fed with 30% fructose solution for eight weeks. Hepatic lipid accumulation was assessed. Hepatic nuclear sterol regulatory element-binding protein (SREBP)-1c was measured. Results showed that hepatic… CONTINUE READING