Endoplasmic reticulum stress is chronically activated in chronic pancreatitis.

@article{Sah2014EndoplasmicRS,
  title={Endoplasmic reticulum stress is chronically activated in chronic pancreatitis.},
  author={Raghuwansh P. Sah and Sushil Kumar Garg and Ajay Kumar Dixit and Vikas Dudeja and Rajinder K. Dawra and Ashok Kumar Saluja},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 40},
  pages={
          27551-61
        }
}
The pathogenesis of chronic pancreatitis (CP) is poorly understood. Endoplasmic reticulum (ER) stress has now been recognized as a pathogenic event in many chronic diseases. However, ER stress has not been studied in CP, although pancreatic acinar cells seem to be especially vulnerable to ER dysfunction because of their dependence on high ER volume and functionality. Here, we aim to investigate ER stress in CP, study its pathogenesis in relation to trypsinogen activation (widely regarded as the… CONTINUE READING
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