Endoplasmic reticulum stress involved in heart and liver injury in iron-loaded rats.

@article{Lou2009EndoplasmicRS,
  title={Endoplasmic reticulum stress involved in heart and liver injury in iron-loaded rats.},
  author={Li-Xia Lou and Bin Geng and Yan Chen and Fang F Yu and Jing Zhao and Chao-shu Tang},
  journal={Clinical and experimental pharmacology & physiology},
  year={2009},
  volume={36 7},
  pages={
          612-8
        }
}
1. Iron overload contributes to the pathogenesis of various diseases and directly induces tissue injury. In the present study, we investigated the relationship between heart and liver injury induced by iron overload and cellular endoplasmic reticulum (ER) stress to explore the molecular mechanism of iron overload-induced cellular injury. 2. Iron overload in rats was generated by intraperitoneal injection of iron-dextran chronically (30 mg/kg per day for 9 weeks) or acutely (300 mg/kg once… CONTINUE READING
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