Endoplasmic reticulum stress inhibits cell cycle progression via induction of p27 in melanoma cells.

@article{Han2013EndoplasmicRS,
  title={Endoplasmic reticulum stress inhibits cell cycle progression via induction of p27 in melanoma cells.},
  author={Chuanchun Han and Lei Yuan Jin and Yide Mei and Mian Wu},
  journal={Cellular signalling},
  year={2013},
  volume={25 1},
  pages={
          144-9
        }
}
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), a stress signaling pathway. The UPR coordinates the induction of ER chaperones with decreased protein synthesis and growth arrest in G1 phase of the cell cycle. However, the molecular mechanism underlying UPR-induced G1 cell cycle arrest remains largely unknown. Here we report that activation of the UPR response by tunicamycin (TM), an ER stress inducer, leads to accumulation of… CONTINUE READING
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