Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain.

@article{Sokka2007EndoplasmicRS,
  title={Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain.},
  author={Anna-Leena Sokka and Noora Putkonen and Giuseppa Mud{\`o} and Evgeny Pryazhnikov and Sami Reijonen and Leonard S Khiroug and Natale Belluardo and Dan Lindholm and Laura T Korhonen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2007},
  volume={27 4},
  pages={901-8}
}
Elevated brain glutamate with activation of neuronal glutamate receptors accompanies neurological disorders, such as epilepsy and brain trauma. However, the mechanisms by which excitotoxicity triggers neuronal injury are not fully understood. We have studied the glutamate receptor agonist kainic acid (KA) inducing seizures and excitotoxic cell death. KA caused the disintegration of the endoplasmic reticulum (ER) membrane in hippocampal neurons and ER stress with the activation of the ER… CONTINUE READING
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