Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis.

@article{Ho2012EndoplasmicRS,
  title={Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis.},
  author={Yuen-Shan Ho and Xifei Yang and Jeffery Chi-Fai Lau and Clara Hui-Ling Hung and Suthicha Wuwongse and Qishan Zhang and Jianzhi Wang and Larry S. Baum and K So and Raymond Chuen-Chung Chang},
  journal={Journal of Alzheimer's disease : JAD},
  year={2012},
  volume={28 4},
  pages={839-54}
}
Accumulation of unfolded proteins can disturb the functions of the endoplasmic reticulum (ER), leading to ER-stress or unfolded protein response (UPR). Recent data have shown that activation of UPR can be found in postmortem brains of Alzheimer's disease (AD) patients; and biological markers for activation of UPR are abundant in neurons with diffuse phosphorylated tau. Although these observations suggest a linkage between ER-stress and tau pathology, little is known of their relationship. In… CONTINUE READING
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