Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2+-dependent and caspase-independent mechanism.

@article{Dolai2011EndoplasmicRS,
  title={Endoplasmic reticulum stress-induced apoptosis in Leishmania through Ca2+-dependent and caspase-independent mechanism.},
  author={Subhankar Dolai and Swati Pal and Rajesh K. Yadav and Subrata Adak},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 15},
  pages={
          13638-46
        }
}
Numerous reports have shown that mitochondrial dysfunctions play a major role in apoptosis of Leishmania parasites, but the endoplasmic reticulum (ER) stress-induced apoptosis in Leishmania remains largely unknown. In this study, we investigate ER stress-induced apoptotic pathways in Leishmania major using tunicamycin as an ER stress inducer. ER stress activates the expression of ER-localized chaperone protein BIP/GRP78 (binding protein/identical to the 78-kDa glucose-regulated protein) with… CONTINUE READING

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