Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes.

@article{Lipson2006EndoplasmicRS,
  title={Endoplasmic reticulum stress-induced apoptosis and auto-immunity in diabetes.},
  author={Kathryn L. Lipson and Sonya G. Fonseca and Fumihiko Urano},
  journal={Current molecular medicine},
  year={2006},
  volume={6 1},
  pages={71-7}
}
Increasing evidence suggests that stress signaling pathways emanating from the endoplasmic reticulum (ER) are important to the pathogenesis of both type 1 and type 2 diabetes. Recent observations indicate that ER stress signaling participates in maintaining the ER homeostasis of pancreatic beta-cells. Either a high level of ER stress or defective ER stress signaling in beta-cells may cause an imbalance in ER homeostasis and lead to beta-cell apoptosis and autoimmune response. In addition, it… CONTINUE READING

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