Endoplasmic reticulum stress in immunity.

Abstract

Immune responses occur in the midst of a variety of cellular stresses that can severely perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three-pronged signaling axis dedicated to preserving ER homeostasis. In this review, we highlight many important and emerging functional roles for ER stress in immunity, focusing on how the… (More)
DOI: 10.1146/annurev-immunol-032414-112116

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