Endoplasmic reticulum stress in health and disease.

  title={Endoplasmic reticulum stress in health and disease.},
  author={Lihong Zhao and Susan L Ackerman},
  journal={Current opinion in cell biology},
  volume={18 4},
Unfolded proteins and other conditions affecting endoplasmic reticulum (ER) homeostasis cause ER stress. The cell reacts to ER stress by activation of the unfolded protein response (UPR), which induces profound changes in cellular metabolism including general translation attenuation, transcriptional upregulation of molecular chaperone genes, and activation of ER-associated degradation. However, prolonged or acute ER stress results in cell death. Recent progress suggests that ER stress and UPR… CONTINUE READING
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