Endoplasmic reticulum stress implicated in the development of renal fibrosis.

  title={Endoplasmic reticulum stress implicated in the development of renal fibrosis.},
  author={Chih-Kang Chiang and Shih-Ping Hsu and C Wu and Jenq-Wen Huang and Hui-Teng Cheng and Yi-Wen Chang and K A Hung and Kuan-Dun Wu and Shing Hwa Liu},
  journal={Molecular medicine},
  volume={17 11-12},
Endoplasmic reticulum (ER) stress-associated apoptosis plays a role in organ remodeling after insult. The effect of ER stress on renal tubular damage and fibrosis remains controversial. This study aims to investigate whether ER stress is involved in tubular destruction and interstitial fibrosis in vivo. Renal cell apoptosis was proven by terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) stain and poly-ADP ribose polymerase expression in the unilateral ureteral obstruction… CONTINUE READING


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