Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation.

@article{Oh2012EndoplasmicRS,
  title={Endoplasmic reticulum stress controls M2 macrophage differentiation and foam cell formation.},
  author={Jisu Oh and Amy E. Riek and Sherry Weng and Marvin Petty and David Hong Kyun Kim and Marco Colonna and Marina Cella and Carlos Bernal-Mizrachi},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 15},
  pages={11629-41}
}
Macrophages are essential in atherosclerosis progression, but regulation of the M1 versus M2 phenotype and their role in cholesterol deposition are unclear. We demonstrate that endoplasmic reticulum (ER) stress is a key regulator of macrophage differentiation and cholesterol deposition. Macrophages from diabetic patients were classically or alternatively stimulated and then exposed to oxidized LDL. Alternative stimulation into M2 macrophages lead to increased foam cell formation by inducing… CONTINUE READING
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