Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells.

@article{King2016EndoplasmicRS,
  title={Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells.},
  author={Yih-An King and Yu-Jen Chiu and Hao-Ping Chen and D H Kuo and Chi-Cheng Lu and J. Yang},
  journal={Environmental toxicology},
  year={2016},
  volume={31 3},
  pages={314-28}
}
Arsenic trioxide is an old drug and has been used for a long time in traditional Chinese and Western medicines. However, the cancer treatment of arsenic trioxide has heart and vascular toxicity. The cytotoxic effects of arsenic trioxide and its molecular mechanism in human umbilical mesenchymal stem cells (HUMSC) and human bone marrow-derived mesenchymal stem cells (HMSC-bm) were investigated in this study. Our results showed that arsenic trioxide significantly reduced the viability of HUMSC… CONTINUE READING