Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro.

@article{Sun2004EndoplasmicRS,
  title={Endoplasmic reticulum stress as a correlate of cytotoxicity in human tumor cells exposed to diindolylmethane in vitro.},
  author={Shishinn Sun and Jing Han and Walter M Ralph and Alamelu Chandrasekaran and Kai Liu and Karen J. Auborn and Timothy H. Carter},
  journal={Cell stress & chaperones},
  year={2004},
  volume={9 1},
  pages={
          76-87
        }
}
The dietary phytochemical indole-3-carbinol (I3C) protects against cervical cancer in animal model studies and in human clinical trials. I3C and its physiologic condensation product diindolylmethane (DIM) also induce apoptosis of tumor cells in vitro and in vivo, suggesting that these phytochemicals might be useful as therapeutic agents as well as for cancer prevention. Deoxyribonucleic acid microarray studies on transformed keratinocytes and tumor cell lines exposed to pharmacologic… CONTINUE READING
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