Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle.

@article{Vattemi2004EndoplasmicRS,
  title={Endoplasmic reticulum stress and unfolded protein response in inclusion body myositis muscle.},
  author={G Vattemi and W. King Engel and Janis McFerrin and Valerie Askanas},
  journal={The American journal of pathology},
  year={2004},
  volume={164 1},
  pages={1-7}
}
Proteins in the endoplasmic reticulum (ER) require an efficient system of molecular chaperones whose role is to assure their proper folding and to prevent accumulation of unfolded proteins. The response of cells to accumulation of unfolded proteins in the ER is termed "unfolded protein response" (UPR). UPR is a functional mechanism by which cells attempt to protect themselves against ER stress, resulting from the accumulation of the unfolded/misfolded proteins. Because intracellular inclusions… CONTINUE READING
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