Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1.

@article{Smith2008EndoplasmicRS,
  title={Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1.},
  author={Judith A. Smith and Matthew J Turner and Monica L Delay and Erin I Klenk and Dawn Paxson Sowders and Robert A. Colbert},
  journal={European journal of immunology},
  year={2008},
  volume={38 5},
  pages={1194-203}
}
Type I IFN are strongly induced upon engagement of certain pattern recognition receptors by microbial products, and play key roles in regulating innate and adaptive immunity. It has become apparent that the endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR), in addition to restoring ER homeostasis, also influences the expression of certain inflammatory cytokines. However, the extent to which UPR signaling regulates type I IFN remains unclear. Here we show that cells… CONTINUE READING

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