Endoplasmic reticulum stress and pancreatic β-cell death.

  title={Endoplasmic reticulum stress and pancreatic β-cell death.},
  author={Sonya G. Fonseca and Jesper Gromada and Fumihiko Urano},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={22 7},
In pancreatic β-cells, the endoplasmic reticulum (ER) is an important cellular compartment for insulin biosynthesis, which accounts for half of the total protein production in these cells. Protein flux through the ER must be carefully monitored to prevent dysregulation of ER homeostasis and stress. ER stress elicits a signaling cascade known as the unfolded… CONTINUE READING