Endoplasmic reticulum stress and endothelial dysfunction.

  title={Endoplasmic reticulum stress and endothelial dysfunction.},
  author={Stefania Lenna and Rong Han and Maria Trojanowska},
  journal={IUBMB life},
  volume={66 8},
Prolonged perturbation of the endoplasmic reticulum (ER) leads to ER stress and unfolded protein response (UPR) and contributes to the pathogenesis of various chronic disorders. This review focuses on the role of ER stress and UPR in endothelial cells and the relevance of these processes to vascular diseases. Chronic activation of ER stress and UPR pathways in endothelial cells leads to increased oxidative stress and inflammation and often results in cell death. Because endothelial cells play a… CONTINUE READING
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