Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis.

@article{Biagioli2008EndoplasmicRS,
  title={Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis.},
  author={Marta Biagioli and Simone Pifferi and Matilde Ragghianti and Stefania Bucci and Rosario Rizzuto and Paolo Pinton},
  journal={Cell calcium},
  year={2008},
  volume={43 2},
  pages={
          184-95
        }
}
Cadmium, a toxic environmental contaminant, exerts adverse effects on different cellular pathways such as cell proliferation, DNA damage and apoptosis. In particular, the modulation of Ca(2+) homeostasis seems to have an important role during Cd(2+) injury, but the precise assessment of Ca(2+) signalling still remains poorly understood. We used aequorin-based probes specifically directed to intracellular organelles to study Ca(2+) changes during cadmium injury. We observed that cadmium… CONTINUE READING
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