Endoplasmic reticulum stress and Nrf2 signaling in cardiovascular diseases.

  title={Endoplasmic reticulum stress and Nrf2 signaling in cardiovascular diseases.},
  author={Luciano Cominacini and Chiara Mozzini and Ulisse Garbin and Andrea Pasini and Chiara Stranieri and Erika Solani and Paola Vallerio and Irene Alessandra Tinelli and Anna Maria Fratta Pasini},
  journal={Free radical biology & medicine},
  volume={88 Pt B},
Various cellular perturbations implicated in the pathophysiology of human diseases, including cardiovascular and neurodegenerative diseases, diabetes mellitus, obesity, and liver diseases, can alter endoplasmic reticulum (ER) function and lead to the abnormal accumulation of misfolded proteins. This situation configures the so-called ER stress, a form of intracellular stress that occurs whenever the protein-folding capacity of the ER is overwhelmed. Reduction in blood flow as a result of… CONTINUE READING
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