Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.

@article{Papa2012EndoplasmicRS,
  title={Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.},
  author={Feroz R Papa},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2012},
  volume={2 9},
  pages={
          a007666
        }
}
Overwhelming of protein folding in the endoplasmic reticulum (ER)--referred to as "ER stress"--activates a set of intracellular signaling pathways termed the unfolded protein response (UPR). Beneficial outputs of the UPR promote adaptation in cells experiencing manageably low levels of ER stress. However, if ER stress reaches critically high levels, the UPR uses destructive outputs to trigger programmed cell death. Genetic mutations in various UPR components cause inherited syndromes of… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 56 CITATIONS, ESTIMATED Infinity% COVERAGE

56 Citations

0510'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 56 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…