Endoplasmic reticulum retention and rescue by heteromeric assembly regulate human ERG 1a/1b surface channel composition.

@article{Phartiyal2008EndoplasmicRR,
  title={Endoplasmic reticulum retention and rescue by heteromeric assembly regulate human ERG 1a/1b surface channel composition.},
  author={Pallavi Phartiyal and H Dastmalchi Sale and Eugenia M C Jones and Gail A Robertson},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 7},
  pages={3702-7}
}
Defects in the trafficking of subunits encoded by the human ether-à-go-go-related gene (hERG1) can lead to catastrophic arrhythmias and sudden cardiac death due to a reduction in I(Kr)-mediated repolarization. Native I(Kr) channels are composed of two alpha subunits, hERG 1a and 1b. In heterologous expression systems, hERG 1b subunits efficiently produce current only in heteromeric combination with hERG 1a. We used Western blot analysis and electrophysiological recordings in HEK-293 cells and… CONTINUE READING