Endoplasmic reticulum-resident protein 57 (ERp57) oxidatively inactivates human transglutaminase 2.

@article{Yi2018EndoplasmicRP,
  title={Endoplasmic reticulum-resident protein 57 (ERp57) oxidatively inactivates human transglutaminase 2.},
  author={Michael C Yi and Arek V Melkonian and James A Ousey and Chaitan Khosla},
  journal={The Journal of biological chemistry},
  year={2018},
  volume={293 8},
  pages={2640-2649}
}
Transglutaminase 2 (TG2) is a ubiquitously expressed, intracellular as well as extracellular protein with multiple modes of post-translational regulation, including an allosteric disulfide bond between Cys-370-Cys-371 that renders the enzyme inactive in the extracellular matrix. Although recent studies have established that extracellular TG2 is switched "on… CONTINUE READING