Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives

@article{Obacz2017EndoplasmicRP,
  title={Endoplasmic reticulum proteostasis in glioblastoma—From molecular mechanisms to therapeutic perspectives},
  author={Joanna Obacz and Tony Avril and Pierre-Jean Le Reste and Hery Urra and V{\'e}ronique Quillien and Claudio Hetz and Eric Chevet},
  journal={Science Signaling},
  year={2017},
  volume={10}
}
Cellular stress induced by the accumulation of misfolded proteins at the endoplasmic reticulum (ER) is a central feature of secretory cells and is observed in many tissues in various diseases, including cancer, diabetes, obesity, and neurodegenerative disorders. Cellular adaptation to ER stress is achieved by the activation of the unfolded protein response (UPR), an integrated signal transduction pathway that transmits information about the protein folding status at the ER to the cytosol and… CONTINUE READING
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