Endoplasmic reticulum proteins in cardiac development and dysfunction.

  title={Endoplasmic reticulum proteins in cardiac development and dysfunction.},
  author={Daniel Prins and Marek Michalak},
  journal={Canadian journal of physiology and pharmacology},
  volume={87 6},
An understanding of cardiac pathologies and the molecular mechanisms thereof is essential for the development of therapies for cardiovascular disease, a common cause of death in Western societies. Investigations into heart diseases have shown that the endoplasmic reticulum and its diverse functions may lie at the center of many cardiac pathologies. Animal models have demonstrated that in numerous cases, faulty endoplasmic reticulum activity is manifested in defective cardiogenesis or impaired… CONTINUE READING


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