Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B.

@article{GillianDaniel2002EndoplasmicRL,
  title={Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B.},
  author={Donald L Gillian-Daniel and Paul W. Bates and Angie Tebon and Alan D Attie},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 7},
  pages={4337-42}
}
Mutations in the low density lipoprotein (LDL) receptor (LDLR) cause hypercholesterolemia because of inefficient LDL clearance from the circulation. In addition, there is a paradoxical oversecretion of the metabolic precursor of LDL, very low density lipoprotein (VLDL). We recently demonstrated that the LDLR mediates pre-secretory degradation of the major VLDL protein, apolipoprotein B (apoB). Kinetic studies suggested that the degradation process is initiated in the secretory pathway. Here, we… CONTINUE READING
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