Endoplasmic reticulum-associated degradation is required for cold adaptation and regulation of sterol biosynthesis in the yeast Saccharomyces cerevisiae.

@article{Loertscher2006EndoplasmicRD,
  title={Endoplasmic reticulum-associated degradation is required for cold adaptation and regulation of sterol biosynthesis in the yeast Saccharomyces cerevisiae.},
  author={Jennifer Loertscher and Lynnelle L Larson and Clinton K. Matson and Mark L. Parrish and Alicia M. Felthauser and Aaron M. Sturm and Christine Tachibana and M. Elizabeth Bard and Robin F. Wright},
  journal={Eukaryotic cell},
  year={2006},
  volume={5 4},
  pages={
          712-22
        }
}
Endoplasmic reticulum-associated degradation (ERAD) mediates the turnover of short-lived and misfolded proteins in the ER membrane or lumen. In spite of its important role, only subtle growth phenotypes have been associated with defects in ERAD. We have discovered that the ERAD proteins Ubc7 (Qri8), Cue1, and Doa10 (Ssm4) are required for growth of yeast that express high levels of the sterol biosynthetic enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR). Interestingly, the… CONTINUE READING
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