Endoplasmic reticulum and cis-Golgi localization of human T-lymphotropic virus type 1 p12(I): association with calreticulin and calnexin.

@article{Ding2001EndoplasmicRA,
  title={Endoplasmic reticulum and cis-Golgi localization of human T-lymphotropic virus type 1 p12(I): association with calreticulin and calnexin.},
  author={Wei Ding and Bjoern Albrecht and Rui Luo and Wenhong Zhang and John R. Stanley and G. C. Newbound and Michael D. Lairmore},
  journal={Journal of virology},
  year={2001},
  volume={75 16},
  pages={7672-82}
}
Human T-lymphotropic virus type 1 (HTLV-1) is a complex retrovirus encoding regulatory and accessory genes in four open reading frames (ORF I to IV) of the pX region. We have demonstrated an important role of pX ORF I expression, which encodes p12(I), in establishment of HTLV-1 infection in a rabbit model and for optimal viral infectivity in quiescent primary lymphocytes. These data indicated that p12(I) may enhance lymphocyte activation and thereby promote virus infection. To further define… CONTINUE READING
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