Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells.

  title={Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells.},
  author={I-Chun Kuo and Huang-Kai Kao and Yenlin Huang and Chun-I Wang and Jui-Shan Yi and Ying Liang and Chun-Ta Liao and Tzu-Chen Yen and Chih-Ching Wu and Kai-Ping Chang},
Oral cavity squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide and associated with poor prognosis and mortality. Discovery of proteins that can improve OSCC treatment is needed. Using comparative proteome profiling of primary cells derived from OSCC and adjacent noncancerous epithelium, endoplasmic reticulum aminopeptidases 2 (ERAP2) has been identified as an OSCC-associated protein. Compared with the adjacent normal tissues, ERAP2 levels were determined to be… 

Figures and Tables from this paper

ERAP2 as a potential biomarker for predicting gemcitabine response in patients with pancreatic cancer

Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) was identified as a biomarker promoting gemcitabine resistance, and its high expression resulted in a worse prognosis, thus providing an effective therapeutic strategy for pancreatic cancer treatment.

The association of XRCC1 polymorphism with osteosarcoma risk, clinicopathologic features, and prognosis in a Chinese Han population

Findings revealed that XRCC1 rs3213245 polymorphism was associated with increased risk of OS, which could affect XR CC1 expression in vitro and in vivo.

Endoplasmic Reticulum Associated Aminopeptidase 2 (ERAP2) Is Released in the Secretome of Activated MDMs and Reduces in vitro HIV-1 Infection

The addition of rhERAP2 to PBMC and CD8−PBMC cultures resulted in the reduction of viral replication, though these differences were statistically significant only in PBMCs, and data herein indicate that exogenous ERAP2-FL exerts its protective function against HIV-1 infection, even in HomoB subjects who do not genetically produce it.

The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy

The role of the biochemical pathway of antigen presentation in cancer is reviewed and how it can be modulated to enhance the efficacy of cancer immunotherapy is discussed.

Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application.

The state-of-the-art in the development of inhibitors of ERAP1 and ERAP2 are reviewed as well as their potential and limitations for clinical applications.

Double Labeling and Simultaneous Monitoring for Hsp70 and Hsf-1 Kinetics in SCC-25 Cells with a Short-Term Dietary Restriction of Leucine Following Heat Shock

The combination of thermotherapy and short-term leucine deprivation therapy may become effective approach for the treatment of oral tumors.



Secretome profiling of primary cells reveals that THBS2 is a salivary biomarker of oral cavity squamous cell carcinoma.

Analysis of the primary cell secretome is a feasible strategy for biomarker identification, and that THBS2 is a potentially useful salivary marker for the detection of OSCC is indicated.

Overexpression of Activin A in Oral Squamous Cell Carcinoma: Association with Poor Prognosis and Tumor Progression

Findings suggest that activin A overexpression in oral squamous cell carcinomas is associated with patients’ survival and may contribute to tumor progression and metastasis.

A Novel Molecular Signature Identified by Systems Genetics Approach Predicts Prognosis in Oral Squamous Cell Carcinoma

This study identified a candidate molecular signature associated with poor prognosis in OSCC patients, which may ultimately facilitate patient-tailored selection of therapeutic strategies.

Identification of candidate nasopharyngeal carcinoma serum biomarkers by cancer cell secretome and tissue transcriptome analysis: Potential usage of cystatin A for predicting nodal stage and poor prognosis

Analysis of both the cancer cell secretome and tissue transcriptome is a feasible strategy for efficient identification of novel NPC serum marker panel, and shows that a three‐marker panel can contribute to a better NPC detection than each marker alone.

Saliva proteome profiling reveals potential salivary biomarkers for detection of oral cavity squamous cell carcinoma

Oral cavity squamous cell carcinoma (OSCC), which is frequently associated with poor prognosis and mortality, is a leading cause of cancer‐related death worldwide. Discovery of body fluid accessible

Endoplasmic reticulum aminopeptidase 2 is highly expressed in papillary thyroid microcarcinoma with cervical lymph node metastasis.

Gen expression profiles and molecular markers of CLNM would help to decide to either do or not do cervical lymph node dissection which might increase morbidities, and ERAP2 might be associated with CLNM in PTMC.

Association between gene expression profile and tumor invasion in oral squamous cell carcinoma.

Identification of a Gene Expression Signature Associated with Recurrent Disease in Squamous Cell Carcinoma of the Head and Neck

Of particular interest was the association of a gene expression signature enriched for genes involved in tumor invasion and metastasis with patients experiencing locally recurrent disease, suggesting that modulation of tumor-specific immune responses may play a role in local treatment failure in HNSCC.

Macrophage Inflammatory Protein-3α Is a Novel Serum Marker for Nasopharyngeal Carcinoma Detection and Prediction of Treatment Outcomes

Serum MIP-3α levels were significantly higher in untreated patients, recurrent patients and patients with distant metastases versus non-NPC controls, patients with complete remission, and long-term disease-free patients, and a high association between MIP -3α level, EBV DNA load, and disease status was revealed.