Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells.

@article{Kuo2017EndoplasmicRA,
  title={Endoplasmic reticulum aminopeptidase 2 involvement in metastasis of oral cavity squamous cell carcinoma discovered by proteome profiling of primary cancer cells.},
  author={I-Chun Kuo and Huang-Kai Kao and Yenlin Huang and Chun-I Wang and Jui-Shan Yi and Ying Liang and Chun-Ta Liao and Tzu-Chen Yen and Chih-Ching Wu and Kai-Ping Chang},
  journal={Oncotarget},
  year={2017}
}
Oral cavity squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide and associated with poor prognosis and mortality. Discovery of proteins that can improve OSCC treatment is needed. Using comparative proteome profiling of primary cells derived from OSCC and adjacent noncancerous epithelium, endoplasmic reticulum aminopeptidases 2 (ERAP2) has been identified as an OSCC-associated protein. Compared with the adjacent normal tissues, ERAP2 levels were determined to be… 

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