Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain.

@article{Paschen2003EndoplasmicRA,
  title={Endoplasmic reticulum: a primary target in various acute disorders and degenerative diseases of the brain.},
  author={Wulf Paschen},
  journal={Cell calcium},
  year={2003},
  volume={34 4-5},
  pages={365-83}
}
Changes in neuronal calcium activity in the various subcellular compartments have divergent effects on affected cells. In the cytoplasm and mitochondria, where calcium activity is normally low, a prolonged excessive rise in free calcium levels is believed to be toxic, in the endoplasmic reticulum (ER), in contrast, calcium activity is relatively high and severe stress is caused by a depletion of ER calcium stores. Besides its role in cellular calcium signaling, the ER is the site where membrane… CONTINUE READING