Endoplasmic Reticulum Stress in Hearing Loss

@inproceedings{Wang2017EndoplasmicRS,
  title={Endoplasmic Reticulum Stress in Hearing Loss},
  author={Yanfei Wang and Xiangguo Liu and Zhigang Xu},
  year={2017}
}
The endoplasmic reticulum (ER) plays important roles in coordinating protein biosynthesis and secretion in the cell. Accumulation of misfolded and/or unfolded proteins in the ER causes ER stress and the so-called unfolded protein response (UPR). The UPR alleviates ER stress through blocking protein synthesis and activating expression of chaperone genes, whereas prolonged UPR could induce cell death. Recent research has showed that ER stress and UPR are involved in hearing loss. Accordingly… CONTINUE READING

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