Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells.

@article{Chen2015EndoplasmicRS,
  title={Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells.},
  author={Si Chen and Zhuhong Zhang and Yuanfeng Wu and Qiang Shi and H. -C. Yan and Nan Mei and William H. Tolleson and Lei Guo},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2015},
  volume={146 1},
  pages={116-26}
}
The use of usnic acid as a weight loss agent is a safety concern due to reports of acute liver failure in humans. Previously we demonstrated that usnic acid induces apoptosis and cytotoxicity in hepatic HepG2 cells. We also demonstrated that usnic acid induces autophagy as a survival mechanism against its cytotoxicity. In this study, we investigated and characterized further molecular mechanisms underlying the toxicity of usnic acid in HepG2 cells. We found that usnic acid causes endoplasmic… CONTINUE READING
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