Endoplasmic Reticulum Stress-Sensing Mechanism Is Activated in Entamoeba histolytica upon Treatment with Nitric Oxide

@inproceedings{SantiRocca2012EndoplasmicRS,
  title={Endoplasmic Reticulum Stress-Sensing Mechanism Is Activated in Entamoeba histolytica upon Treatment with Nitric Oxide},
  author={Julien Santi-Rocca and Sherri Smith and Christian Weber and Erika Pineda and Chung-Chau Hon and Emma Saavedra and Alfonso Olivos-Garc{\'i}a and Sandrine Rousseau and Marie-Agn{\`e}s Dillies and Jean-Yves Copp{\'e}e and Nancy Guillen},
  booktitle={PloS one},
  year={2012}
}
The Endoplasmic Reticulum stores calcium and is a site of protein synthesis and modification. Changes in ER homeostasis lead to stress responses with an activation of the unfolded protein response (UPR). The Entamoeba histolytica endomembrane system is simple compared to those of higher eukaryotes, as a canonical ER is not observed. During amoebiasis, an infection of the human intestine and liver by E. histolytica, nitric oxide (NO) triggers an apoptotic-like event preceded by an impairment of… CONTINUE READING
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