Endoplasmic Reticulum Stress Pathway-Mediated Apoptosis in Macrophages Contributes to the Survival of Mycobacterium tuberculosis

@inproceedings{Lim2011EndoplasmicRS,
  title={Endoplasmic Reticulum Stress Pathway-Mediated Apoptosis in Macrophages Contributes to the Survival of Mycobacterium tuberculosis},
  author={Yun-Ji Lim and Ji-Ae Choi and Hong-Hee Choi and Soo-Na Cho and Hwa-Jung Kim and Eun Kyeong Jo and Jeong-kyu Park and Chang-Hwa Song},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Apoptosis is thought to play a role in host defenses against intracellular pathogens, including Mycobacterium tuberculosis (Mtb), by preventing the release of intracellular components and the spread of mycobacterial infection. This study aims to investigate the role of endoplasmic reticulum (ER) stress mediated apoptosis in mycobacteria infected macrophages. METHODOLOGY/PRINCIPAL FINDINGS Here, we demonstrate that ER stress-induced apoptosis is associated with Mtb H37Rv-induced… CONTINUE READING
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