Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

  title={Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes},
  author={Umut Özcan and Q. Cao and E. Yılmaz and A. Lee and N. Iwakoshi and Esra Özdelen and G{\"u}rol Tuncman and C. G{\"o}rg{\"u}n and L. Glimcher and G. Hotamisligil},
  pages={457 - 461}
  • Umut Özcan, Q. Cao, +7 authors G. Hotamisligil
  • Published 2004
  • Biology, Medicine
  • Science
  • Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show that obesity causes endoplasmic reticulum (ER) stress. This stress in turn leads to suppression of insulin receptor signaling through hyperactivation of c-Jun N-terminal kinase (JNK) and subsequent serine phosphorylation of insulin receptor substrate–1 (IRS-1). Mice deficient in X-box–binding protein–1 (XBP-1), a transcription factor that… CONTINUE READING
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