Endoplasmic Reticulum Stress Disulfide Isomerases to Abrogate Survival Responses to Increasing Melanoma Cell Death Using Inhibitors of Protein

Abstract

Exploiting vulnerabilities in the intracellular signaling pathways of tumor cells is a key strategy for the development of new drugs. The activation of cellular stress responses mediated by the endoplasmic reticulum (ER) allows cancer cells to survive outside their normal environment. Many proteins that protect cells against ER stress are active as protein… (More)

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