Endoplasmic Reticulum Stress Activates the Hepatic Activator Protein 1 Complex via Mitogen Activated Protein Kinase-Dependent Signaling Pathways

@inproceedings{Olivares2014EndoplasmicRS,
  title={Endoplasmic Reticulum Stress Activates the Hepatic Activator Protein 1 Complex via Mitogen Activated Protein Kinase-Dependent Signaling Pathways},
  author={Shantel Olivares and Richard M. Green and Anne S. Henkel},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND AND AIMS Endoplasmic reticulum (ER) stress is induced in many forms of chronic liver disease and may promote the development of hepatocellular carcinoma. The activator protein 1 (AP-1) complex is a transcription factor that promotes hepatic carcinogenesis in response to cellular stress. The aim of this study was to determine the role of ER stress in the regulation of the hepatic AP-1 complex. METHODS Human hepatocellular carcinoma (HepG2) cells and C57BL/6J mice were subjected to… CONTINUE READING

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