Endoplasmic Reticulum (ER) Stress and Endocrine Disorders

  title={Endoplasmic Reticulum (ER) Stress and Endocrine Disorders},
  author={Daisuke Ariyasu and H. Yoshida and Y. Hasegawa},
  journal={International Journal of Molecular Sciences},
  • Daisuke Ariyasu, H. Yoshida, Y. Hasegawa
  • Published 2017
  • Biology, Medicine
  • International Journal of Molecular Sciences
  • The endoplasmic reticulum (ER) is the organelle where secretory and membrane proteins are synthesized and folded. Unfolded proteins that are retained within the ER can cause ER stress. Eukaryotic cells have a defense system called the “unfolded protein response” (UPR), which protects cells from ER stress. Cells undergo apoptosis when ER stress exceeds the capacity of the UPR, which has been revealed to cause human diseases. Although neurodegenerative diseases are well-known ER stress-related… CONTINUE READING
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