Endophytic Actinomycetes: A Novel Antibiotic Source

  title={Endophytic Actinomycetes: A Novel Antibiotic Source},
  author={Ravi Ranjan Kumar and Vasantba J. Jadeja},
  journal={International Journal of Current Microbiology and Applied Sciences},
  • R. Kumar, V. Jadeja
  • Published 15 August 2016
  • Biology
  • International Journal of Current Microbiology and Applied Sciences
Antibiotics are secondary metabolites produced by some microorganisms to inhibit or kill many other microorganisms including different bacteria, viruses and eukaryotic cells. Antibiotics are secondary metabolites and these have also been termed “idiolites” (Walker, 1974). Subsequent and widespread use of antibiotics for therapeutic purposes regularly in human, veterinary and agricultural purposes were favoring the survival and spread of resistant pathogens. Search for new natural antibiotics… 
Endophytes and Their Applications as Biofertilizers
This compendium will accentuate on the different types of endophytic microorganisms and their extensive role as a biofertilizer in the field of agriculture.
Antimicrobial Activity of Soil Actinomycetes Isolated from Western Ghats in Tamil Nadu, India
Some actinomycetes were isolated from the soil samples collected from Kanyakumari, Tirunelveli, Dindigul, Coimbatore and the Nilgiri districts of Western Ghats in Tamil Nadu, India and two isolates showed very high inhibitory activity against E. faecalis and C. albicans.
  • C. Ajanaku
  • Biology
    Journal of Microbiology, Biotechnology and Food Sciences
  • 2018
The findings reveals Bidens pilosa as a medicinal plant with potentials for the treatment of tuberculosis.
Indo-Pak Medicinal Plants and Their Endophytes: An Emphasis on Nutraceutical and Bioactive Potential
This chapter will focus on the traditional plants of the Indo-Pak region, their endophytes particularly the genus actinomycetes and the recent studies done on their diverse metabolites.


Natural products from endophytic microorganisms.
The prospects of finding new drugs that may be effective candidates for treating newly developing diseases in humans, plants, and animals are great and other applications in industry and agriculture may also be discovered among the novel products produced by endophytic microbes.
Studies on Endophytic Actinomycetes ( I ) Streptomyces sp. Isolated from Rhododendron and Its Antifungal Activity
The present results indicate that isolate R-5 is a suitable candidate for the biocontrol of diseases of rhododendron and can produce antifungal material(s).
An Endophytic Actinomycete, Streptomyces sp. AOK-30, Isolated from Mountain Laurel and Its Antifungal Activity
The present results indicate that isolate AOK-30 is a potential biocontrol agent against diseases of mountain laurel.
Multiple, Novel Biologically Active Endophytic Actinomycetes Isolated from Upper Amazonian Rainforests
This work isolated 14 actinomycete species from a collection of approximately 300 plant stem samples from the upper Amazonian rainforest in Peru, providing evidence of the untapped biodiversity in the form of biologically active microbes present within the tissues of higher plants.
Munumbicins E-4 and E-5: novel broad-spectrum antibiotics from Streptomyces NRRL 3052.
It appears that other bioactive compounds, related to E-4 and E-5, are also produced making it the most biologically active endophytic Streptomyces spp.
Cedarmycins A and B, new antimicrobial antibiotics from Streptomyces sp. TP-A0456.
Two novel butyrolactone antibiotics, cedarmycins A and B, were isolated from the cultured broth of the actinomycete Streptomyces sp. TP-A0456. The new compounds were purified by HP-20 resin, silica
Interaction of endophytic microbes with legumes
A high amount of progress is required to fully understand the mechanism of establishment, the way interactions take place in planta, between different microbes and plants and exlusive benefits by endophytes and plants.
Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans.
Munumbicins A, B, C and D are newly described antibiotics with a wide spectrum of activity against many human as well as plant pathogenic fungi and bacteria, and a Plasmodium sp. These compounds were
Biosynthetic Potential of Phylogenetically Unique Endophytic Actinomycetes from Tropical Plants
The results suggest that tropical plants from New Guinea and the adjacent archipelago are hosts to unique endophytic actinomycetes that possess significant biosynthetic potential.
Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp.
Coronamycin is a complex of novel peptide antibiotics with activity against pythiaceous fungi and the human fungal pathogen Cryptococcus neoformans and other compounds with antifungal activities are also produced by this endophytic streptomycete.