Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation.

@article{Ambroso2014EndophilinAI,
  title={Endophilin A1 induces different membrane shapes using a conformational switch that is regulated by phosphorylation.},
  author={Mark R. Ambroso and Balachandra Hegde and Ralf Langen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 19},
  pages={
          6982-7
        }
}
Membrane remodeling is controlled by proteins that can promote the formation of highly curved spherical or cylindrical membranes. How a protein induces these different types of membrane curvature and how cells regulate this process is still unclear. Endophilin A1 is a protein involved in generating endocytotic necks and vesicles during synaptic endocytosis and can transform large vesicles into lipid tubes or small and highly curved vesicles in vitro. By using EM and electron paramagnetic… CONTINUE READING
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