Endophenotypes, Epigenetics, Polygenicity and More: Irv Gottesman's Dynamic Legacy.


First, we describe the hallmark contributions of Irv Gottesman's pioneering scholarship for schizophrenia research including concepts of polygenicity, gene × environment interactions, epigenetics and the endophenotype concept. Gottesman and colleagues' twin studies showed that genes, not social factors, mediate schizophrenia risk. He then showed that… (More)
DOI: 10.1093/schbul/sbw157


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