Endophenotype properties of niacin sensitivity as marker of impaired prostaglandin signalling in schizophrenia.

@article{Smesny2007EndophenotypePO,
  title={Endophenotype properties of niacin sensitivity as marker of impaired prostaglandin signalling in schizophrenia.},
  author={Stefan Smesny and Silke Klemm and Margit Stockebrand and Sebastian Grunwald and U J Gerhard and Timm Rosburg and Heinrich Sauer and Bernhard Blanz},
  journal={Prostaglandins, leukotrienes, and essential fatty acids},
  year={2007},
  volume={77 2},
  pages={79-85}
}
BACKGROUND Disruption of arachidonic acid pathways and prostaglandin signalling has been implicated in the pathophysiology of schizophrenia. AIMS We intended to study prostaglandin signalling in groups of young schizophrenia patients, first-degree relatives, and healthy controls in order to assess effects of heritability on this biological marker-one important endophenotype criterion. METHOD Namely, we assessed intensity of methylnicotinate skin flushing using optical reflection… CONTINUE READING

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