Endonucleolytic Function of MutLα in Human Mismatch Repair

@article{Kadyrov2006EndonucleolyticFO,
  title={Endonucleolytic Function of MutLα in Human Mismatch Repair},
  author={Farid A Kadyrov and Leonid Dzantiev and Nicoleta Constantin and Paul Modrich},
  journal={Cell},
  year={2006},
  volume={126},
  pages={297-308}
}
Half of hereditary nonpolyposis colon cancer kindreds harbor mutations that inactivate MutLa (MLH1 PMS2 heterodimer). MutLa is required for mismatch repair, but its function in this process is unclear. We show that human MutLa is a latent endonuclease that is activated in a mismatch-, MutSa-, RFC-, PCNA-, and ATP-dependent manner. Incision of a nicked mismatch-containing DNA heteroduplex by this four-protein system is strongly biased to the nicked strand. A mismatch-containing DNA segment… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
36 Citations
34 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

Similar Papers

Loading similar papers…