Endonuclease-responsive aptamer-functionalized hydrogel coating for sequential catch and release of cancer cells.

@article{Li2013EndonucleaseresponsiveAH,
  title={Endonuclease-responsive aptamer-functionalized hydrogel coating for sequential catch and release of cancer cells.},
  author={Shihui Li and Niancao Chen and Zhaoyang Zhang and Yong Wang},
  journal={Biomaterials},
  year={2013},
  volume={34 2},
  pages={460-9}
}
Rare circulating tumor cells are a promising biomarker for the detection, diagnosis, and monitoring of cancer. However, it remains a challenge to develop biomedical devices for specific catch and nondestructive release of circulating tumor cells. The purpose of this study was to explore a unique system for cell catch and release by using aptamer-functionalized hydrogels and restriction endonucleases. The results show that the hydrogel coating was highly resistant to nonspecific cell binding… CONTINUE READING

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